The entrepreneurial landscape in many economies is shaped by a dynamic mix of migrant and indigenous businesses, each facing unique opportunities and challenges that influence their survival and growth. This article presents a comparative analysis of the survival strategies, structural barriers, and enabling factors affecting both migrant-owned and indigenous enterprises. Drawing on qualitative and quantitative data from diverse sectors, the study explores how access to social capital, regulatory environments, cultural integration, and resource constraints impact business longevity. Particular attention is given to the role of community networks, market adaptability, and institutional support in navigating these factors. Findings indicate that while migrant businesses often demonstrate high resilience and innovation, they face systemic challenges such as limited access to finance and regulatory complexity. Indigenous businesses, in contrast, benefit from contextual familiarity but may lack the agility seen in migrant enterprises. The article concludes with policy recommendations aimed at fostering inclusive entrepreneurship ecosystems that support the sustainability of both business groups, contributing to local economic development and social cohesion.